Mushroom Science

Maitake Gold 404®

Sale price Price $45.95 Regular price Unit price  per 

Add 6 Maitake Gold 404® to the cart to get 10% off! Discount automatically applied on checkout page.

Lot# 14229, Exp.Date 10/26




Dose Instructions Chart

Other ingredients: Vegetable Glycerin, Distilled Water

Suggested use: Shake well before using. As a dietary supplement take 4 drops twice a day.

Warnings: Keep out of reach of children. Do not use if allergic to mushrooms, pregnant or nursing. Safety sealed for your protection. Do not purchase if seal is broken or missing.

Product Description

Maitake Gold 404® Mushroom Extract

MaitakeGold 404® is a potent Maitake mushroom extract developed by Dr. Hiroaki Nanba, PhD., the inventor of Maitake nutraceuticals. MaitakeGold represents such a significant improvement in Maitake formulations that it was granted a U.S. Patent (U.S. Patent # 5,854,404), and is the only Maitake supplement that carries Dr. Nanba’s personal endorsement.

Maitake is the only medicinal mushroom that can be hot water extracted and sold in a liquid form and still provide an effective dose for immune support. MaitakeGold 404® is a hot water extract preserved in glycerin, offering an alcohol free supplement for immune support.*

The other liquid mushroom supplements on the market are preserved in alcohol and are called tinctures, also known as “cold water extracts”. These products contain very low levels of active compounds, including the key immuno-modulating compounds, the polysaccharides, that define a mushroom as medicinal. This is because tinctures are processed at room temperature, far below the temperatures required for hot water extraction. Tincturing works for plants but not mushrooms or mushroom mycelium.

Medicinal mushrooms are prepared as hot water extracts in 100% of the herbal and scientific references for a reason, it is the only preparation method capable of releasing the active compounds from the indigestible cell walls of mushrooms and mushroom mycelium and into a bioavailable form.


*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Evolution of MaitakeGold 404®

In the early 1980s, Dr. Hiroaki Nanba, a professor of microbiology and an expert mycologist at Kobe Pharmaceutical University, was intensively studying the medicinal properties of various mushrooms. During this time much of his attention was devoted to the popular Shiitake mushroom. However, his research showed him that Maitake had a unique molecular structure that exhibited greater immune activating power than the other medicinal mushroom extracts he had been working with.*

He also discovered that the immune benefits Maitake provided worked well when the extract was taken orally. The highly concentrated beta glucan extract from Shiitake, known as Lentinan, only worked when injected.*

In 1984, Dr. Nanba isolated an important Maitake fraction (or specialized component) that stimulated macrophages. According to the studies, this Maitake fraction also had the ability to directly enhance the activity of Natural Killer (NK) cells and to change NK precursor cells into activated NK cells.*

Using a special extraction method these Maitake fractions were concentrated to produce a standardized liquid polysaccharide extract containing beta-1,6 1,3 glucan, now sold under the brand name MaitakeGold 404®.  Later in his research, Dr. Nanba patented the extraction process for MaitakeGold 404®.

Standardized MaitakeGold Liquid or Full Spectrum Capsules?

Does this standardized version of Maitake offer any advantages over the Full Spectrum Maitake extract?

All of the components found in the MaitakeGold 404® are also contained in the full spectrum Maitake extract.  The research also demonstrates that MaitakeGold 404® and the full spectrum Maitake extracts have the same health benefits and the same effect on the immune system.*

In short, the fractioning process used to produce MaitakeGold 404® does not add or detract from the inherent bioactivity or immune benefits offered by the Maitake mushroom.*

The one advantage the MaitakeGold 404® has over the Full Spectrum Maitake capsules is that MaitakeGold is more concentrated, so it can be sold in the liquid form. Many people have difficulty swallowing capsules, so the liquid form is a significant advantage in these cases.

However, many other people prefer a full spectrum extract that contains all of the minor compounds.  Given that both versions have been found to offer significant but equal immune health benefits in the published research it is, for the most part, a matter of personal preference.*


There are no references for Maitake in the Chinese herbal texts. However, Japanese herbalists have long used Maitake tea as an adaptogen, to help balance the various systems and functions of the body in times of stress.

Most importantly, the Maitake polysaccharides have been found to balance, stimulate and support the immune system, the bodies’ internal defense system against external invaders. These were the properties that made Maitake valuable in Japanese herbalism, and it was this traditional use that caught the attention of modern researchers.*

Add 6 Maitake Gold 404® to the cart to get 10% off! Discount applied on checkout page.