Coriolus PSP - Turkey Tail

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Other names: Trametes versicolor, Turkey Tail Mushroom

Other ingredients: Vegetarian capusules (cellulose), Coriolus versicolor mycelium, myceliated rice.

Suggested use: Adults, take 1-3 capsules, twice daily, on an empty stomach.

Warnings: Keep out of reach of children. Do not use if allergic to mushrooms, pregnant or breast feeding. Do not use if safety seal around top of bottle is missing or broken. Store at room temperature, with lid closed.

Product Description

Coriolus PSP (Coriolus versicolor)
a.k.a. Trametes versicolor or Turkey Tail Mushroom

Coriolus PSP is one of the most effective and best selling immune support supplements in the world. With health benefits verified by hundreds of studies and multiple human clinical trials, it is also one of the most thoroughly researched medicinal mushroom supplements used for immune support.*

Turkey Tail Mushroom

Also called the Turkey Tail mushroom or Trametes versicolor, Coriolus versicolor enjoys a long history of use and recognition in Traditional Chinese Medicine, with appearances in traditional herbal texts dating as far back as the early 15th century. Coriolus PSP was developed by Dr. Yang of the Shanghai Teachers College in the 1980’s. Contrary to what some companies claim, PSP and PSK can be produced from any strain of Coriolus versicolor and can be extracted from the mushroom fruit bodies or the mycelium, as long as the mycelium is grown through submerged culture in a liquid medium. 


The research on Coriolus PSP has focused on the exact same biological activities as the research on Coriolus Super Strength (PSK), supporting immune health.*


  1. Coriolus Super Strength (PSK) has more protein than peptide in the non-glucan portion of the molecule. Coriolus PSP has more peptide than protein in the non-glucan portion of the molecule.
  2. There are minor differences in the non-active single sugars.
  3. The glucan (polysaccharide) portions of Coriolus Super Strength (PSK) and Coriolus PSP, the part considered to be the primary active compound, are identical under NMR analysis.
  4. Coriolus Super Strength (PSK) is 40% polysaccharide, Coriolus PSP is 28%.
  5. Coriolus Super Strength (PSK) has 600 mg of extract powder per capsule, Coriolus PSP has 400 mg of extract powder per capsule.
  6. There has been more research done on the protein-bound form of Coriolus (Super Strength/PSK) as compared to the polysaccharide-peptide form of Coriolus (PSP), but the academics, the scientists that study this medicinal mushroom, believe PSK and PSP are of equal value for immune support purposes.*


The Coriolus extract called PSP (Polysaccharide-Peptide), was first developed in China during the late 1980’s, about 15 years after the first studies on the Japanese extract PSK were published (a.k.a. Krestin or Coriolus Super Strength).

The main difference between the two extracts is quite simple: PSP contains both peptides and proteins in the non-glucan portion of the molecule but contains more peptides than proteins.  PSK (a.k.a. Coriolus Super Strength), also contains both peptides and proteins in the non-glucan portion of the molecule but contains more proteins than peptides.

PSP is classified as a polysaccharide-peptide, PSK is classified as a protein-bound polysaccharide.

There are also minor differences in the non-active single sugars.

However, the glucan portion of both PSP and PSK (a.k.a. Coriolus Super Strength), the part considered to be biologically active for immune support purposes, is identical under NMR analysis (Nuclear Magnetic Resonance Imaging).*

This difference in the peptide-protein ratio between PSP and PSK (a.k.a. Coriolus Super Strength), is due to the fact that precipitation with alcohol is used as a secondary step in the extraction process for PSP.

Precipitation with alcohol was first developed by Chinese researchers and represents a significant and important innovation in the hot water extraction process for medicinal mushrooms.

The “old” method of separating the bio-active heavy molecular weight polysaccharides from the lighter weight non-active single sugars was to use evaporation alone (after the hot water extraction step).

The lighter molecular weight single sugars are the first compounds to be separated from the hot water extract mixture as they leave with the evaporated steam, prior to the spray drying step that converts the concentrate to a powder.

The heavier molecular weight polysaccharides that contain the beta glucans, because they are in fact heavier, remain in solution after a significant percentage of the single sugars are evaporated out.  However, this is a lengthy and energy intensive process.

What the Chinese did was to use the natural properties of the active compounds, the polysaccharides that contain the beta glucans, to speed up the process of concentrating them prior to spray drying.

The bio-active polysaccharides in medicinal mushrooms are not alcohol soluble.  So after the initial hot water extraction step, the Chinese researchers began adding alcohol to the liquid extract solution.  At a certain concentration of added alcohol, the heavy molecular weight polysaccharides that contain the beta glucans will separate, while still in solution, from the single sugars.

After the heavy molecular weight polysaccharides separate from the other non-active single sugars, they are siphoned off into the evaporation tank for further concentration.

As opposed to using evaporation alone, using precipitation with alcohol first is a much faster and far more efficient way to concentrate and separate the active compounds from the non-active single sugars.

Although the beta glucan portion of the molecule is not affected by precipitation with alcohol, this process does release some of the protein links in the long-chain polysaccharide molecule.  This reduces the mass, resulting in those portions of the molecule to be re-classified as peptide links instead of protein links.

That is why Coriolus PSP is classified as a polysaccharide-peptide and has more peptides than proteins, when compared to Coriolus Super Strength (PSK).  Coriolus Super Strength and PSK have more proteins than peptides and are classified as protein-bound polysaccharides.

The general consensus in the scientific community is that PSP and PSK (Coriolus Super Strength) are of equal value for immune support when dosed out in equal amounts, milligram for milligram, of the active compounds.*


Decoctions of Coriolus versicolor have been used for centuries in Traditional Chinese Medicine (TCM), with references in the Chinese Compendium of Materia Medica dating as far back as the 15th century.

Coriolus versicolor is called “Yun zhi” in Chinese.  The Ming dynasty edition of the Materia Medica states that “The black and green Yun zhi are beneficial to one’s spirit and vital energy, and strengthen one’s tendon and bone.”*

According to the references from TCM Coriolus is sweet in taste and slightly warm in nature, acting through the spleen and heart meridians. It dispels damp and reduces phlegm.* In TCM, all the references have Coriolus prepared as a hot-water extract.  There are no references from TCM citing the use of ground up Coriolus mushrooms or tinctures of Coriolus.

 *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.